I recently started going through entire seasons of TV series on Netflix and so far I have fallen in love with Californication. Now that's a damn show! My other favorite was The X Files, also with David Duchovny. Fringe to fill the gap the show left in the sci-fi genre for the '00s but it was an abject failure. I dropped it after the first season.
I enjoy House but have little patience for the predictably schmaltzy social commentary. C'mon, every patient cannot possibly be some kind of spokesperson for whatever retarded obsession he has!
As far as Lost, I discovered it on Netflix earlier this year and went through all five seasons in something like two months. Grades suffered. Girlfriend complained. Tummy rumbled. But I finished it. Soon as I was done, season six started—I dropped it after the third episode. The plot is lost (if you'll allow). The show has generally fallen into the same rut in which Fringe wallowed from the beginning, wherein characters go around acting "dramatic" and "alarmed" over, um... nothing particularly meaningful. "Jacob said I was chosen!" "What?! You? Hm...I guess I can't kill you now as I was about to two minutes ago."
This whole pseudo-spiritual "who will lead the island" mumbo jumbo has completely ruined the series. It has collapsed beneath the weight of its own overwrought mythology. The delightfully conflicted Sawyer character has been robbed of all his threat and the Jack character has gone from an admirable hero valiantly struggling to overcome his own faults to a listless, disoriented puppy. Evangeline Lilly has aged ten years within the span of two seasons. Random plot connections are created arbitrarily. Jack and Kate siblings? Give me a break. What a shame.
Other stuff I like are classic '80s stuff like MacGuyver and Knight Rider. I'm generally a sucker for '80s stuff, the cornier the better.
What I should do now is go watch some Deadwood 'cause I've seen it mentioned repeatedly in this thread. Must be good! I should also check out Oz, which I never really paid much attention to.